Select Recent Publications
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Lymphatic dysfunction in lupus contributes to cutaneus photosensitivity and lymph node B cell responses.
Ambler WG, Howlader M, Laha S Chalasani M, Seltzer ES, Sim JH, Shin J, Schwartz N, Shipman WD, Dasoveanu DC, Carballo CB, Sevin E, Siddique S, Rodeo S, Erkan D, Kataru P, Merhara B, Lu TT. https://www.biorxiv.org/content/10.1101/2022.06.13.495930v2 and in revision.
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The interferon-rich skin environment regulates Langerhans cell ADAM17 to promote photosensitivity in lupus.
Li TM, Zyulina V, Seltzer ES, Dacic M, Chinenov Y, Daamen AR, Veiga KR, Schwartz N, Oliver DJ, Lora J, Jabbari A, Liu Y, Shipman WD, Ambler WG, Taber SF, Onel JB, Zippin JH, Rashighi M, Krueger JG, Anandasabapathy N, Rogatsky I, Blobel CP, Lipsky PE, Lu TT. BioRxiv. https://www.biorxiv.org/content/10.1101/2021.08.18.456792v4 and submitted for peer review.
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Advances in understanding and examining lymphatic function: relevance for understanding autoimmunity.
Ambler W, Santambrogio L, Lu TT. Curr Opin Rheumatol. 2022 Mar 1;34(2):133-138. doi: 10.1097/BOR.0000000000000864. PMID: 34954700
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T2B or not to B: Calming neutrophils offshore
Munir H, Lu TT. J Exp Med. 2021 Sep 6;218(9):e20211407. doi: 10.1084/jem.20211407. Epub 2021 Aug 10. PMID: 34374712
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Immune Cell-Stromal Circuitry in Lupus Photosensitivity
Sim JH, Ambler WG, Sollohub IF, Howlader MJ, Li TM, Lee HJ, Lu TT. J Immunol. 2021 Jan 15;206(2):302-309. doi: 10.4049/jimmunol.2000905. PMID: 33397744 Review.
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Fibroblast subtypes in tissues affected by autoimmunity: with lessons from lymph node fibroblasts
Shipman WD, Sandoval MJ, Veiga K, Donlin LT, Lu TT. Curr Opin Immunol. 2020 May 5;64:63-70. doi: 10.1016/j.coi.2020.03.002. PMID: 32387902 Review.
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Lymph node stromal CCL2 limits antibody responses
Dasoveanu DC, Park HJ, Ly CL, Shipman WD, Chyou S, Kumar V, Tarlinton D, Ludewig B, Mehrara BJ, Lu TT. Sci Immunol. 2020 Mar 20;5(45):eaaw0693. doi: 10.1126/sciimmunol.aaw0693. PMID: 32198221
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Role of type I interferons and innate immunity in systemic sclerosis: unbalanced activities on distinct cell types?
Barrat FJ, Lu TT. Curr Opin Rheumatol. 2019 Nov;31(6):569-575. doi: 10.1097/BOR.0000000000000659. PMID: 31436583 Review.
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Lymphatic Function in Autoimmune Diseases
Schwartz N, Chalasani MLS, Li TM, Feng Z, Shipman WD, Lu TT. Front Immunol. 2019 Mar 20;10:519. doi: 10.3389/fimmu.2019.00519. eCollection 2019. PMID: 30949174 Review.
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A protective Langerhans cell-keratinocyte axis that is dysfunctional in photosensitivity
Shipman WD, Chyou S, Ramanathan A, Izmirly PM, Sharma S, Pannellini T, Dasoveanu DC, Qing X, Magro CM, Granstein RD, Lowes MA, Pamer EG, Kaplan DH, Salmon JE, Mehrara BJ, Young JW, Clancy RM, Blobel CP, Lu TT. Sci Transl Med. 2018 Aug 15;10(454):eaap9527. doi: 10.1126/scitranslmed.aap9527. PMID: 30111646
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Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis
Chia JJ, Zhu T, Chyou S, Dasoveanu DC, Carballo C, Tian S, Magro CM, Rodeo S, Spiera RF, Ruddle NH, McGraw TE, Browning JL, Lafyatis R, Gordon JK, Lu TT. J Clin Invest. 2016 Nov 1;126(11):4331-4345. doi: 10.1172/JCI85740. Epub 2016 Oct 10. PMID: 27721238
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Regulation of Lymph Node Vascular-Stromal Compartment by Dendritic Cells
Dasoveanu DC, Shipman WD, Chia JJ, Chyou S, Lu TT. Trends Immunol. 2016 Nov;37(11):764-777. doi: 10.1016/j.it.2016.08.013. Epub 2016 Sep 13. PMID: 27638128 Review.
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A dendritic-cell-stromal axis maintains immune responses in lymph nodes
Kumar V, Dasoveanu DC, Chyou S, Tzeng TC, Rozo C, Liang Y, Stohl W, Fu YX, Ruddle NH, Lu TT. Immunity. 2015 Apr 21;42(4):719-30. doi: 10.1016/j.immuni.2015.03.015. PMID: 25902483